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Analysis of institutional authors

Portal-Nunez, SergioAuthorArias Macias, Caridad MAuthorBruna Del Cojo, MartaAuthorAdell-Perez, CarlosAuthorAdell-Perez, AnaCorresponding Author

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January 11, 2024
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Does a Dysbiotic Oral Microbiome Trigger the Risk of Chronic Inflammatory Disease?

Publicated to:Curr Treat Options Allergy. 10 (4): 364-383 - 2023-12-27 10(4), DOI: 10.1007/s40521-023-00355-4

Authors: Jimenez De Nunzio, Sofia; Portal-Nunez, Sergio; Arias Macias, Caridad M; Bruna Del Cojo, Marta; Adell-Perez, Carlos; Latorre Molina, Maria; Macias-Gonzalez, Manuel; Adell-Perez, Ana

Affiliations

CEU Univ, Univ San Pablo CEU, Fac Med, Dept Odontol, Boadilla Del Monte 28660, Spain - Author
CEU Univ, Univ San Pablo CEU, Fac Med, Grp Fisiopatol Osea,Dept Ciencias Med Basicas,Inst, Boadilla Del Monte 28660, Spain - Author
Facultad de Medicina. Universidad CEU San Pablo - Author
Inst Salud Carlos III, Spanish Biomed Res Ctr Physiopathol Obes & Nutr CI, Madrid, Spain - Author
Med Dept Vitaldent, Barcelona, Spain - Author
Spiral DNA Tech Corp, Spiral, Madrid, Spain - Author
Univ Malaga, Inst Biomed Res Malaga IBIMA Bionand Platform, Malaga, Spain - Author
Universidad CEU San Pablo. CC MEDICINA. Odontologia - Author
Virgen Victoria Univ Hosp, Dept Endocrinol & Nutr, Malaga, Spain - Author
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Abstract

Purpose of ReviewThis paper studies the different mechanisms that link oral dysbiosis and various inflammatory diseases.Recent FindingsOral bacteria have been found in atherosclerotic plaques. Experiments in mouse models have shown that after inoculation with Porphyromonas gingivalis, there is a higher brain barrier permeability. Fusobacterium nucleatum is present in higher amounts in patients with colorectal cancer than in healthy subjects. Porphyromonas gingivalis, along with other oral bacteria, has a strong capacity for peptide citrullination, which increases the risk of developing rheumatoid arthritis.SummaryDifferent epidemiological and experimental studies have indicated a positive correlation between a dysbiotic oral microbiome and a higher risk of developing Alzheimer's disease, colorectal cancer, cardiovascular diseases, type 2 diabetes, and rheumatoid arthritis. Additionally, experimental studies of patients with inflammatory diseases have demonstrated that after periodontal treatment, their inflammatory conditions improved. These findings show that there is a strong link between the oral microbiome and the development of inflammatory diseases but that periodontal interventions could be beneficial in the treatment and management of the progression of these diseases.

Keywords

Chronic diseasesHealthInfectionInflammationNonsurgical periodontal treatmentOral dysbiosisOral microbiomeRheumatoid-arthritisType-2 diabetes-mellitus

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Curr Treat Options Allergy, and although the journal is classified in the quartile Q3 (Agencia WoS (JCR)), its regional focus and specialization in Allergy, give it significant recognition in a specific niche of scientific knowledge at an international level.

From a relative perspective, and based on the normalized impact indicator calculated from the Field Citation Ratio (FCR) of the Dimensions source, it yields a value of: 2.69, which indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: Dimensions Jul 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-07-07, the following number of citations:

  • WoS: 2
  • Scopus: 3

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-07-07:

  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 16 (PlumX).

Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (Jimenez De Nunzio, Sofia) and Last Author (ADELL PEREZ, ANA).

the author responsible for correspondence tasks has been ADELL PEREZ, ANA.