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Analysis of institutional authors

Sevillano JAuthorSánchez-Alonso MgAuthorRamos-álvarez MdpAuthor

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June 12, 2024
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Role of Receptor Protein Tyrosine Phosphatases (RPTPs) in Insulin Signaling and Secretion.

Publicated to:International Journal Of Molecular Sciences. 22 (11): - 2021-05-28 22(11), DOI: https://doi.org/10.3390/ijms22115812

Authors: Sevillano J; Sánchez-Alonso MG; Pizarro-Delgado J; Ramos-Álvarez MDP

Affiliations

Department of Chemistry and Biochemistry, Facultad de Farmacia, Universidad San Pablo-CEU, CEU Universities, Urbanización Montepríncipe, Alcorcón, 28925 Madrid, Spain. - Author

Abstract

Changes in lifestyle in developed countries have triggered the prevalence of obesity and type 2 diabetes mellitus (T2DM) in the latest years. Consequently, these metabolic diseases associated to insulin resistance, and the morbidity associated with them, accounts for enormous costs for the health systems. The best way to face this problem is to identify potential therapeutic targets and/or early biomarkers to help in the treatment and in the early detection. In the insulin receptor signaling cascade, the activities of protein tyrosine kinases and phosphatases are coordinated, thus, protein tyrosine kinases amplify the insulin signaling response, whereas phosphatases are required for the regulation of the rate and duration of that response. The focus of this review is to summarize the impact of transmembrane receptor protein tyrosine phosphatase (RPTPs) in the insulin signaling cascade and secretion, and their implication in metabolic diseases such as obesity and T2DM.

Keywords

insulin secretioninsulin signalingt2dmAnimalsDiabetes mellitus, type 2HumansInsulinInsulin resistanceInsulin secretionInsulin signalingObesityPrevalenceProtein tyrosine phosphatasesReceptor protein tyrosine phosphatases (rptp)Receptor, insulinReceptor-like protein tyrosine phosphatases, class 2Signal transductionT2dm

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal International Journal Of Molecular Sciences due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2021, it was in position 69/297, thus managing to position itself as a Q1 (Primer Cuartil), in the category Biochemistry & Molecular Biology.

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-07-17:

  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 50 (PlumX).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.

Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (SEVILLANO FERNANDEZ, JULIO) and Last Author (RAMOS ALVAREZ, MARIA DEL PILAR).