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CE

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Analysis of institutional authors

Lõpez-Lõpez AAuthorLópez-Gonzálvez AAuthorGradillas AAuthorBarbas CAuthorGonzález-Ruiz VAuthor

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October 7, 2024
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Article
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CE-MS-Based Clinical Metabolomics of Human Plasma.

Publicated to: Methods in Molecular Biology. 2855 389-423 - 2025-01-01 2855(), DOI: 10.1007/978-1-0716-4116-3_23

Authors:

Mamani-Huanca M; Martínez S; López-López Á; López-Gonzálvez Á; Albóniga OE; Gradillas A; Barbas C; González-Ruiz V
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Affiliations

Centro de Metabolómica y Bioanálisis (CEMBIO), Facultad de Farmacia, Universidad San Pablo-CEU, CEU Universities, Madrid, Spain. - Author
Centro de Metabolómica y Bioanálisis (CEMBIO), Facultad de Farmacia, Universidad San Pablo-CEU, CEU Universities, Madrid, Spain. victor.gonzalezruiz@ceu.es. - Author

Abstract

Capillary electrophoresis coupled to mass spectrometry (CE-MS) has emerged as a powerful analytical technique with significant implications for clinical research and diagnostics. The integration of information from CE and MS strengthens confidence in the identification of compounds present in clinical samples. The ability of CE to separate molecules based on their electrophoretic mobility coupled to MS enables the accurate identification and quantification of analytes, even in complex biological matrices such as human plasma.Here, we present a detailed protocol for an untargeted metabolomics study using CE-MS and its application in a study on human plasma from patients suffering Long COVID syndrome. The protocol ranges from sample preparation to biological interpretation, detailing a workflow enabling the analysis of cationic and anionic compounds, metabolite identification, and data processing.
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Keywords

Ce-msClinical metabolomicsCovid-19Electrophoresis, capillaryHuman plasmaHumansLong covidMass spectrometryMetabolomicsPlasmaPolar metabolomeSars-cov-2Untargeted metabolomics

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Methods in Molecular Biology, Q4 Agency Scopus (SJR), its regional focus and specialization in Genetics, give it significant recognition in a specific niche of scientific knowledge at an international level.

Independientemente del impacto esperado determinado por el canal de difusión, es importante destacar el impacto real observado de la propia aportación.

Según las diferentes agencias de indexación, el número de citas acumuladas por esta publicación hasta la fecha 2026-04-11:

  • Scopus: 1
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Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2026-04-11:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 6.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 6 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 7.
  • The number of mentions on the social network X (formerly Twitter): 10 (Altmetric).
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Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (Mamani-Huanca M) and Last Author (González Ruiz, Víctor).

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