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Review

Supplementation with Folic Acid or 5-Methyltetrahydrofolate and Prevention of Neural Tube Defects: An Evidence-Based Narrative Review

Publicated to:Nutrients. 16 (18): 3154- - 2024-09-01 16(18), DOI: 10.3390/nu16183154

Authors: Samaniego-Vaesken, Maria de Lourdes; Morais-Moreno, Carmen; Carretero-Krug, Alejandra; Puga, Ana Maria; Montero-Bravo, Ana Maria; Partearroyo, Teresa; Gregorio, Varela-Moreiras

Affiliations

CEU Univ, Univ San Pablo CEU, Fac Farm, Inst Univ CEU Alimentac & Soc,Urbanizac Monteprinc, Boadilla Del Monte 28660, Spain - Author
CEU Univ, Univ San Pablo CEU, Grp USP CEU Excelencia Nutr Vida Nutr Life,Urbaniz, Dept Ciencias Farmaceut & Salud,Fac Farm,Ref E02 0, Boadilla Del Monte 28660, Spain - Author

Abstract

Keywords
5-methyltetrahydrofolateAnimalsBlood folate concentrationsDietary supplementsEvidence-based medicineFemaleFolatesFolic acidFor-gestational-ageFortificationHomocysteineHomocysteine concentrationsHumansKiller-cell cytotoxicityMethylenetetrahydrofolate reductaseNeural tube defectsNtNtdPlasma homocysteinePregnancyRisSupplementationTetrahydrofolatesWomen

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Nutrients due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2024 there are still no calculated indicators, but in 2023, it was in position 18/114, thus managing to position itself as a Q1 (Primer Cuartil), in the category Nutrition & Dietetics.

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-05-23:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 23.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 22 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 19.3.
  • The number of mentions on the social network X (formerly Twitter): 12 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.
Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (SAMANIEGO VAESKEN, Mª LOURDES) and Last Author (VARELA MOREIRAS, GREGORIO).

the author responsible for correspondence tasks has been VARELA MOREIRAS, GREGORIO.