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Analysis of institutional authors

Saiz, JorgeAuthorBarbas, CoralCorresponding Author

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February 27, 2025
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Neurons regulate the esterification of bioactive lipid mediators in the brain of acid sphingomyelinase deficient mice

Publicated to: PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY. 129 110896- - 2024-02-08 129(), DOI: 10.1016/j.pnpbp.2023.110896

Authors:

Taha, AY; Gaudioso, A; Moran-Garrido, M; Camunas-Alberca, SM; Bachiller-Hernández, J; Sáiz, J; Ledesma, MD; Barbas, C
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Affiliations

CEU Univ, Univ San Pablo, Fac Farm, Ctr Metabol & Bioanal CEMBIO,Dept Chem & Biochem, Madrid 28660, Spain - Author
UAM, Ctr Biol Mol Severo Ochoa, CSIC, Madrid 28049, Spain - Author
Univ Calif Davis, Coll Agr & Environm Sci, Dept Food Sci & Technol, Davis, CA 95616 USA - Author
Univ Calif Davis, Ctr Neurosci, 1 Shields Ave, Davis, CA 95616 USA - Author
Univ Calif Davis, West Coast Metabol Ctr, Genome Ctr, Davis, CA 95616 USA - Author
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Abstract

Acid sphingomyelinase deficiency is a neurodegenerative lysosomal storage disorder caused by mutations in the sphingomyelin-degrading enzyme acid sphingomyelinase (ASM) gene. Upregulated neuroinflammation has been well-characterized in an ASM knockout mouse model of acid sphingomyelinase deficiency disease, but lipid mediator pathways involved in 'mediating' inflammation and inflammation-resolution have yet to be charac-terized. In this study, we 1) measured free (bioactive) and esterified (inactive) lipid mediators involved in inflammation and inflammation resolution in cerebellum and neuronal cultures of ASM knockout (ASMko) mice and wildtype (WT) controls, and 2) quantified the esterification of labeled pro-resolving free d11-14(15)-epoxyeicosatrienoic acid in cultured neurons from ASMko and WT mice. We found elevated concentrations of esterified pro-resolving lipid mediators and hydroxyeicosatrienoic acids typically destined for pro-resolving lipid mediator synthesis (e.g. lipoxins) in the cerebellum and neurons of ASMko mice compared to controls. Free d11-14(15)-epoxyeicosatrienoic acid esterification within neurons of ASMko mice was significantly elevated compared to WT. Our findings show evidence of increased inactivation of free pro-resolving lipid mediators through esterification in ASMko mice, suggesting impaired resolution as a new pathway underlying ASM defi-ciency pathogenesis.
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Keywords

AnimalsBound oxylipinsBrainEsterificationFree oxylipinsInflammationMiceMice, knockoutNeurodegenerationNeuroinflammatioNeuroinflammationNeuronsNiemann pick diseaseNiemann-pick disease, type aNiemann-pick diseasesSphingomyelin phosphodiesteraseSphingomyelins

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2024 there are still no calculated indicators, but in 2023, it was in position 55/288, thus managing to position itself as a Q1 (Primer Cuartil), in the category Psychiatry.

Independientemente del impacto esperado determinado por el canal de difusión, es importante destacar el impacto real observado de la propia aportación.

Según las diferentes agencias de indexación, el número de citas acumuladas por esta publicación hasta la fecha 2026-04-06:

  • WoS: 6
  • Scopus: 7
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Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2026-04-06:

  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 7 (PlumX).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.
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Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: United States of America.

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: Last Author (BARBAS ARRIBAS, CORAL).

the author responsible for correspondence tasks has been BARBAS ARRIBAS, CORAL.

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Awards linked to the item

This work was funded by a fellowship of the Wylder Nation Foundation to A.G. and by grants from the Spanish Ministry of Science and Innovation (PID2020-112830RB-I00) (AEI/FEDER,UE) and the Next Generation EU-CSIC funds (NeuroAging) to M.D.L. Additional support to A.Y.T. was provided by USDA National Institute of Food and Agriculture, Hatch/Taha (project #1008787) . M.M and S.M.C. acknowledge their predoctoral fellowship from the Spanish Ministry of Universities with references FPU19/06206 and FPU21/01142 respectively.r Foundation to A.G. and by grants from the Spanish Ministry of Science and Innovation (PID2020-112830RB-I00) (AEI/FEDER,UE) and the Next Generation EU-CSIC funds (NeuroAging) to M.D.L. Additional support to A.Y.T. was provided by USDA National Institute of Food and Agriculture, Hatch/Taha (project #1008787) . M.M and S.M.C. acknowledge their predoctoral fellowship from the Spanish Ministry of Universities with references FPU19/06206 and FPU21/01142 respectively.
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