Novel risk loci for COVID-19 hospitalization among admixed American populations

Indexed in

License and use

Citations

Cited 1 times in Europe PMC logo

Altmetrics

Grant support

Instituto de Salud Carlos III COV20_00622 Angel Carracedo Instituto de Salud Carlos III COV20/00792 Matilde Bustos Instituto de Salud Carlos III COV20_00181 Carmen Ayuso Instituto de Salud Carlos III COV20_1144 Amanda Fernandez-Rodriguez Maria A Jimenez-Sousa Instituto de Salud Carlos III PI20/00876 Carlos Flores European Regional Development Fund A way of making Europe Angel Carracedo Fundacion Amancio Ortega Angel Carracedo Banco Santander Angel Carracedo Estrella de Levante S.A. Encarna Guillen-Navarro Colabora Mujer Association Encarna Guillen-Navarro Obra Social La Caixa Raul C Baptista-Rosas Agencia Estatal de Investigacion RTC-2017-6471-1 Carlos Flores Cabildo Insular de Tenerife CGIEU0000219140 Carlos Flores Fundacion Canaria Instituto de Investigacion Sanitaria de Canarias PIFIISC20/57 Carlos Flores Xunta de Galicia Silvia Diz-de Almeida Axencia GAIN Silvia Diz-de Almeida The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.

Analysis of institutional authors

Lopez Rodriguez, RosarioAuthorPaz Artal, EstelaAuthor

August 9, 2025

Publications

Article

Sí

Novel risk loci for COVID-19 hospitalization among admixed American populations

Publicated to:Elife. 13 RP93666- - 2024-10-03 13(), DOI: 10.7554/eLife.93666

Authors: Diz-de Almeida, Silvia; Cruz, Raquel; Luchessi, Andre D; Lorenzo-Salazar, Jose M; Lopez de Heredia, Miguel; Quintela, Ines; Gonzalez-Montelongo, Rafaela; Nogueira Silbiger, Vivian; Sevilla Porras, Marta; Tenorio Castano, Jair Antonio; Nevado, Julian; Maria Aguado, Jose; Aguilar, Carlos; Aguilera-Albesa, Sergio; Almadana, Virginia; Almoguera, Berta; Alvarez, Nuria; Andreu-Bernabeu, lvaro; Arana-Arri, Eunate; Arango, Celso; Arranz, Maria J; Artiga, Maria-Jesus; Baptista-Rosas, Raul C; Barreda- Sanchez, Maria; Belhassen-Garcia, Moncef; Bezerra, Joao F; Bezerra, Marcos A C; Boix-Palop, Lucia; Brion, Maria; Brugada, Ramon; Bustos, Matilde; Calderon, Enrique J; Carbonell, Cristina; Castano, Luis; Castelao, Jose E; Conde-Vicente, Rosa; Cordero-Lorenzana, M Lourdes; Cortes-Sanchez, Jose L; Corton, Marta; Teresa Darnaude, M; De Martino-Rodriguez, Alba; del Campo-Perez, Victor; de Bustamante, Aranzazu Diaz; Dominguez-Garrido, Elena; Eiros, Rocio; Carmen Farinas, Maria; Fernandez-Nestosa, Maria J; Fernandez-Robelo, Uxia; Fernandez-Rodriguez, Amanda; Fernandez-Villa, Tania; Gago-Dominguez, Manuela; Gil-Fournier, Belen; Gomez-Arrue, Javier; Alvarez, Beatriz Gonzalez; Bernaldo de Quiros, Fernan Gonzalez; Gonzalez-Neira, Anna; Gonzalez-Penas, Javier; Gutierrez-Bautista, Juan F; Herrero, Maria Jose; Herrero-Gonzalez, Antonio; Jimenez-Sousa, Maria A; Claudia Lattig, Maria; Liger Borja, Anabel; Lopez-Rodriguez, Rosario; Mancebo, Esther; Martin-Lopez, Caridad; Martin, Vicente; Martinez-Nieto, Oscar; Martinez-Lopez, Iciar; Martinez-Resendez, Michel F; Martinez-Perez, Angel; Mazzeu, Juliana F; Merayo Macias, Eleuterio; Minguez, Pablo; Cuerda, Victor Moreno; Oliveira, Silviene F; Ortega-Paino, Eva; Parellada, Mara; Paz-Artal, Estela; Santos, Ney P C; Perez-Matute, Patricia; Perez, Patricia; Perez-Tomas, M Elena; Perucho, Teresa; Pinsach-Abuin, Mellina; Pita, Guillermo; Pompa-Mera, Ericka N; Porras-Hurtado, Gloria L; Pujol, Aurora; Ramiro Leon, Soraya; Resino, Salvador; Fernandes, Marianne R; Rodriguez-Ruiz, Emilio; Rodriguez-Artalejo, Fernando; Rodriguez-Garcia, Jose A; Ruiz-Cabello, Francisco; Ruiz-Hornillos, Javier; Ryan, Pablo; Manuel Soria, Jose; Carlos Souto, Juan; Tamayo, Eduardo; Tamayo-Velasco, Alvaro; Taracido-Fernandez, Juan Carlos; Teper, Alejandro; Torres-Tobar, Lilian; Urioste, Miguel; Valencia-Ramos, Juan; Yanez, Zuleima; Zarate, Ruth; de Rojas, Itziar; Ruiz, Agustin; Sanchez, Pascual; Real, Luis Miguel; Guillen-Navarro, Encarna; Ayuso, Carmen; Parra, Esteban; Riancho, Jose A; Rojas-Martinez, Augusto; Flores, Carlos; Lapunzina, Pablo; Carracedo, Angel

Affiliations

Bellvitge Biomed Res Inst IDIBELL, Neurometab Dis Lab, Barcelona, Spain - Author

Biocruces Bizkai HRI, Bizkaia, Spain - Author

Catalan Inst Res & Adv Studies ICREA, Barcelona, Spain - Author

CEI UAM CSIC, IMDEA Food Inst, Madrid, Spain - Author

CHUAC, Serv Med Intens, Sistema Galego Saude SERGAS, La Coruna, Spain - Author

CHUAC, Urgencias Hosp, Sistema Galego Saude SERGAS, La Coruna, Spain - Author

CIBERER, ISCIII, Madrid, Spain - Author

Clin Comfamiliar Risaralda, Pereira, Colombia - Author

Complejo Asistencial Univ Leon, Leon, Spain - Author

Cruces Univ Hosp, Osakidetza, Bizkaia, Spain - Author

Ctr Biomed Res La Rioja CIBIR, CSIC Associated Unit, Infect Dis Microbiota & Metab Unit, Logrono, Spain - Author

Ctr Desarrollo Invest Cient, Asuncion, Paraguay - Author

ERN ITHACA European Reference Network, Soria, Spain - Author

Escola Tecn Saude, Lab Vigilancia Mol Aplicada, Brasilia, DF, Brazil - Author

Fdn Publ Galega Med Xenom, Sistema Galego Saude SERGAS, Santiago De Compostela, Spain - Author

Fdn Rioja Salud, Unidad Diagnost Mol, La Rioja, Spain - Author

Fdn Santa Fe Bogota, Dept Patol & Labs, Bogota, Colombia - Author

Fdn Univ Ciencias Salud, Bogota, Colombia - Author

Fundacio Docencia & Recerca Mutua Terrassa, Barcelona, Spain - Author

GENYCA, Madrid, Spain - Author

Gregorio Maranon Hlth Res Inst IiSGM, Madrid, Spain - Author

Hosp 12 Octubre Imas12, Inst Invest Sanitaria, Transplant Immunol & Immunodef Grp, Madrid, Spain - Author

Hosp Clin Univ Santiago CHUS, Sistema Galego Saude SERGAS, Unidad Cuidados Intens, Santiago De Compostela, Spain - Author

Hosp Clin Univ Valladolid, Serv Anestesiol & Reanimac, Valladolid, Spain - Author

Hosp Clin Univ Valladolid, Serv Hematol & Hemoterapia, Valladolid, Spain - Author

Hosp Clin Univ Virgen de la Arrixaca, Secc Genet Med, Serv Pediat, Serv Murciano Salud, Murcia, Spain - Author

Hosp El Bierzo, Unidad Cuidados Intens, Leon, Spain - Author

Hosp Gen Occidente Seguro Social, Zapopan, Jalisco, Mexico - Author

Hosp Gen Santa Barbara Soria, Soria, Spain - Author

Hosp Gen Segovia, Med Intens, Segovia, Spain - Author

Hosp Gen Univ Gregorio Maranon IiSGM, Inst Psychiat & Mental Hlth, Dept Child & Adolescent Psychiat, Madrid, Spain - Author

Hosp Infanta Elena, Allergy Unit, Madrid, Spain - Author

Hosp Infectol, Ctr Med Nacl La Raza, IMSS, Mexico City, DF, Mexico - Author

Hosp Josep Trueta, Serv Cardiol, Girona, Spain - Author

Hosp Ninos Dr Ricardo Gutierrez, Buenos Aires, DF, Argentina - Author

Hosp Ophir Loyola, Dept Ensino & Pesquisa, Belem, Para, Brazil - Author

Hosp Santa Creu & Sant Pau, Haemostasis & Thrombosis Unit, IIB St Pau, Barcelona, Spain - Author

Hosp Santa Creu & Sant Pau, IIB St Pau, Res Inst, Genom Complex Dis Unit, Barcelona, Spain - Author

Hosp UM Valdecilla, Cantabria, Spain - Author

Hosp Univ 12 Octubre, Dept Immunol, Madrid, Spain - Author

Hosp Univ 12 Octubre, Inst Invest Sanitaria Hosp 12 Octubre Imas12, Infect Dis Unit, Madrid, Spain - Author

Hosp Univ Getafe, Serv Genet, Madrid, Spain - Author

Hosp Univ Infanta Leonor, Madrid, Spain - Author

Hosp Univ La Paz IDIPAZ, Inst Genet Med & Mol INGEMM, Madrid, Spain - Author

Hosp Univ Mostoles, Med Interna, Madrid, Spain - Author

Hosp Univ Mostoles, Unidad Genet, Madrid, Spain - Author

Hosp Univ Mutua Terrassa, Barcelona, Spain - Author

Hosp Univ Nuestra Senora Candelaria, Inst Invest Sanitaria Canarias, Res Unit, Santa Cruz De Tenerife, Spain - Author

Hosp Univ Rio Hortega, Valladolid, Spain - Author

Hosp Univ Salamanca IBSAL, Serv Cardiol, Salamanca, Spain - Author

Hosp Univ Salamanca IBSAL, Serv Med Interna, Salamanca, Spain - Author

Hosp Univ Salamanca IBSAL, Serv Med Interna, Unidad Enfermedades Infecciosas, Salamanca, Spain - Author

Hosp Univ Son Espases, Unidad Diagnost Mol & Genet Clin, Islas Baleares, Spain - Author

Hosp Univ Valme, Unidad Clin Enfermedades Infecciosas & Microbiol, Seville, Spain - Author

Hosp Univ Virgen de las Nieves, Serv Anal Clin & Inmunol, Granada, Spain - Author

Hosp Univ Virgen Macarena, Neumol, Seville, Spain - Author

IACS, Zaragoza, Spain - Author

IdiPaz Inst Invest Sanitaria Hosp Univ La Paz, Madrid, Spain - Author

IDIS, Seongnam, South Korea - Author

IDIVAL, Cantabria, Spain - Author

IIS La Fe, Plataforma Farmacogenet, Valencia, Spain - Author

IMSS, Ctr Med Nacl Siglo XXI, Unidad Invest Med Enfermedades Infecciosas & Para, Mexico City, DF, Mexico - Author

Inditex, La Coruna, Spain - Author

Inst Invest Biomed Girona IDIBGI, Cardiovasc Genet Ctr, Girona, Spain - Author

Inst Invest Biosanitaria Granada Ibs GRANADA, Granada, Spain - Author

Inst Invest Sanitaria Aragon IIS Aragon, Zaragoza, Spain - Author

Inst Invest Sanitaria Galicia Sur, Oncol & Genet Unit, Xerencia Xest Integrada Vigo Serv Galego Saude, Vigo, Spain - Author

Inst Invest Sanitaria Galicia Sur, Xerencia Xest Integrada Vigo, Prevent Med Dept, Serv Galego Saude, Vigo, Spain - Author

Inst Invest Sanitaria Santiago IDIS, Xenet Cardiovasc, Santiago De Compostela, Spain - Author

Inst Murciano Invest Biosanitaria IMIB Arrixaca, Murcia, Spain - Author

Inst Salud Carlos III ISCIII, CNM, Unidad Infecc Viral & Inmunidad, Madrid, Spain - Author

Inst Salud Carlos III, Ctr Biomed Network Res Diabet & Metab Associated, Madrid, Spain - Author

Inst Salud Carlos III, Ctr Biomed Network Res Mental Hlth CIBERSAM, Madrid, Spain - Author

Inst Salud Carlos III, Ctr Biomed Network Res Neurodegenerat Dis CIBERNE, Madrid, Spain - Author

Inst Salud Carlos III, Ctr Biomed Network Res Resp Dis CIBERES, Madrid, Spain - Author

Inst Salud Carlos III, Grp Clin Vinculado, Ctr Biomed Network Res Rare Dis CIBERER, Madrid, Spain - Author

Inst Salud Carlos III, Spanish Network Res Infect Dis REIPI RD16 0016 00, Madrid, Spain - Author

Inst Tecnol & Energias Renovables, Genom Div, Santa Cruz De Tenerife, Spain - Author

ISCIII, CIBERCV, Madrid, Spain - Author

ISCIII, CIBEResp, Madrid, Spain - Author

ISCIII, CIBERINFEC, Madrid, Spain - Author

Minist Salud Ciudad Buenos Aires, Buenos Aires, DF, Argentina - Author

Navarra Hlth Serv Hosp, Dept Pediat, Pediat Neurol Unit, Pamplona, Spain - Author

NavarraBioMed Res Grp, Navarra Hlth Serv, Pamplona, Spain - Author

Otto von Guericke Univ, Dept Micrograv & Translat Regenerat Med, Magdeburg, Germany - Author

Programa Posgrad Biol Anim UnB, Brasilia, DF, Brazil - Author

Programa Posgrad Ciencias Med UnB, Brasilia, DF, Brazil - Author

Programa Posgrad Ciencias Med UnB, Brazila, Brazil - Author

Programa Posgrad Profiss Ensino Biol UnB, Brasilia, DF, Brazil - Author

Queen Sofia Fdn Alzheimer Ctr, CIEN Fdn, Madrid, Spain - Author

Spanish Natl Canc Res Ctr, CNIO Biobank, Madrid, Spain - Author

Spanish Natl Canc Res Ctr, Familial Canc Clin Unit, Madrid, Spain - Author

Spanish Natl Canc Res Ctr, Human Genotyping CEGEN Unit, Madrid, Spain - Author

Tecnol Monterrey, Escuela Med & Ciencias Salud, Monterrey, Mexico - Author

Tecnol Monterrey, Monterrey, Mexico - Author

UAM, Data Anal Dept, IIS FJD, Univ Hosp, Madrid, Spain - Author

UAM, IIS FJD, Fdn Jimenez Diaz Univ Hosp, Dept Genet & Genom, Madrid, Spain - Author

UAM, IIS FJD, Univ Hosp, Madrid, Spain - Author

UCAM, Murcia, Spain - Author

Unidad Genet & Genom Islas Baleares, Islas Baleares, Spain - Author

Univ Autonoma Madrid, Sch Med, Dept Prevent Med & Publ Hlth, Madrid, Spain - Author

Univ Basque Country, UPV EHU, Bizkaia, Spain - Author

Univ Brasilia, Fac Med, Brasilia, DF, Brazil - Author

Univ Brasilia, Inst Ciencias Biol, Dept Genet & Morfol, Brasilia, DF, Brazil - Author

Univ Cantabria, Cantabria, Spain - Author

Univ Complutense Madrid, Dept Immunol Ophthalmol & ENT, Madrid, Spain - Author

Univ Complutense Madrid, Madrid, Spain - Author

Univ Complutense, Sch Med, Madrid, Spain - Author

Univ Fed Para, Nucleo Pesquisas Oncol, Belem, Para, Brazil - Author

Univ Fed Pernambuco, Genet Postgrad Program, Recife, PE, Brazil - Author

Univ Fed Rio Grande do Norte, Dept Anal Clin & Toxicol, Natal, RN, Brazil - Author

Univ Fernando Pessoa Canarias, Dept Clin Sci, Las Palmas Gran Canaria, Spain - Author

Univ Francisco Vitoria, Fac Med, Madrid, Spain - Author

Univ Francisco Vitoria, Madrid, Spain - Author

Univ Girona, Sch Med, Med Sci Dept, Girona, Spain - Author

Univ Granada, Dept Bioquim Biol Mol & Inmunol 3, Granada, Spain - Author

Univ Guadalajara, Ctr Invest Multidisciplinario Salud, Tonala, Jalisco, Mexico - Author

Univ Guadalajara, Ctr Univ Tonala, Tonala, Jalisco, Mexico - Author

Univ Hosp Burgos, Burgos, Spain - Author

Univ Int Catalunya, Ace Alzheimer Ctr Barcelona, Res Ctr & Memory Clin, Barcelona, Spain - Author

Univ Leon, Inst Biomed IBIOMED, GIIGAS, Leon, Spain - Author

Univ Los Andes, Fac Ciencias, Bogota, Colombia - Author

Univ Los Andes, SIGEN Alianza, Fdn Santa Fe Bogota, Bogota, Colombia - Author

Univ Murcia UMU, Fac Med, Dept Cirugia Pediat Obstet & Ginecol, Murcia, Spain - Author

Univ Nacl Asuncion, Fac Politecn, San Lorenzo, Paraguay - Author

Univ Salamanca, Salamanca, Spain - Author

Univ San Pablo CEU, CEU Univ, Fac Farm, Urbanizac Monteprincipe, Boadilla Del Monte, Spain - Author

Univ Santiago de Compostela, Ctr Singular Invest Med Mol & Enfermedades Cron C, Santiago De Compostela, Spain - Author

Univ Seville, Hosp Univ Virgen del Rocio, Dept Med, Seville, Spain - Author

Univ Seville, Virgen del Rocio Univ Hosp, CSIC, Inst Biomed Seville IBiS, Seville, Spain - Author

Univ Simon Bolivar, Fac Ciencias Salud, Barranquilla, Colombia - Author

Univ Toronto, Dept Anthropol, Mississauga, ON, Canada - Author

Univ Valencia, Dept Farmacol, Valencia, Spain - Author

Univ Valladolid, Dept Cirugia, Valladolid, Spain - Author

Abstract

The genetic basis of severe COVID-19 has been thoroughly studied, and many genetic risk factors shared between populations have been identified. However, reduced sample sizes from non-European groups have limited the discovery of population-specific common risk loci. In this second study nested in the SCOURGE consortium, we conducted a genome-wide association study (GWAS) for COVID-19 hospitalization in admixed Americans, comprising a total of 4702 hospitalized cases recruited by SCOURGE and seven other participating studies in the COVID-19 Host Genetic Initiative. We identified four genome-wide significant associations, two of which constitute novel loci and were first discovered in Latin American populations (BAZ2B and DDIAS). A trans-ethnic meta-analysis revealed another novel cross-population risk locus in CREBBP. Finally, we assessed the performance of a cross-ancestry polygenic risk score in the SCOURGE admixed American cohort. This study constitutes the largest GWAS for COVID-19 hospitalization in admixed Latin Americans conducted to date. This allowed to reveal novel risk loci and emphasize the need of considering the diversity of populations in genomic research.

Keywords

AdmixtureAgedAssociationComplexCovid-19FemaleGenetic lociGenetic predisposition to diseaseGeneticsGenome-wide association studyGenomicsGwasHospitalizationHumansLatin americaMaleMetaanalysisMiddle agedNonePolymorphism, single nucleotideRisk factorsSars-cov-2SnSnpTranscriptionZbtb7

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Elife due to its progression and the good impact it has achieved in recent years, according to the agency Scopus (SJR), it has become a reference in its field. In the year of publication of the work, 2024 there are still no calculated indicators, but in 2023, it was in position , thus managing to position itself as a Q1 (Primer Cuartil), in the category . Notably, the journal is positioned above the 90th percentile.

Independientemente del impacto esperado determinado por el canal de difusión, es importante destacar el impacto real observado de la propia aportación.

Según las diferentes agencias de indexación, el número de citas acumuladas por esta publicación hasta la fecha 2025-08-31:

Europe PMC: 1

Impact and social visibility

Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: Argentina; Brazil; Canada; Colombia; Germany; Mexico; Paraguay; Republic of Korea.

Indexed in

License and use

Citations

Altmetrics

Grant support

Analysis of institutional authors

Share

Novel risk loci for COVID-19 hospitalization among admixed American populations

Affiliations

Abstract

Keywords

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

Impact and social visibility

Leadership analysis of institutional authors