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Analysis of institutional authors

Herrera ECorresponding AuthorOrtega-Senovilla HAuthor

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January 25, 2017
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Lipid metabolism during pregnancy and its implications for fetal growth.

Publicated to: CURRENT PHARMACEUTICAL BIOTECHNOLOGY. 15 (1): 24-31-31 - 2014-01-01 15(1), DOI: 10.2174/1389201015666140330192345

Authors:

Herrera, E; Ortega-Senovilla, H
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Affiliations

Univ San Pablo CEU, Fac Pharm & Med, Madrid 28668, Spain - Author
Universidad San Pablo CEU, Ctra. Boadilla del Monte km 5.3, 28668 Madrid, Spain. eherrera@ceu.es. - Author

Abstract

More glucose crosses the placenta than any other substrate, but correlations between its concentration in maternal plasma and fetal growth are not found consistently. The accumulation of maternal fat depots and hyperlipidemia are the two principal changes in lipid metabolism during pregnancy. Although lipids cross the placenta with difficulty, maternal plasma triacylglycerols (TAG) and non-esterified fatty acids (NEFA) correlate with fetal lipids, fetal growth and fat mass under certain conditions. In intrauterine growth restriction, impaired placental transfer of lipophilic compounds (long-chain polyunsaturated fatty acids and lipophilic vitamins) seems to underpin metabolic dysfunction and decreased birth weight. In gestational diabetes mellitus (GDM), maternal TAG and NEFA levels correlate with neonatal anthropometric measures. In GDM, adipocyte fatty acid-binding protein in fetuses correlated with neonatal fat mass; changes in maternal or cord blood leptin, retinol binding protein 4 and adiponectin concentrations have been related to neonatal fat mass or birth weight, although their importance remains to be investigated. The angiopoietin-like protein 4 (ANGPTL-4) is secreted from adipose tissue, liver and placenta, and irreversibly inhibits lipoprotein lipase (LPL) activity. Maternal plasma ANGPTL-4 is decreased in GDM, and it has been proposed to be responsible for an increase in placental LPL activity, which would facilitate a greater fatty acid placental transfer, contributing to the higher fetal fat accumulation. Thus, while evidence suggesting major involvement of maternal lipid metabolism in fetal adiposity and growth exists, the precise mechanisms remain to be elucidated.
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Keywords

Acid-binding proteinAdipocytokinesAdipose tissueAngiopoietin-like proteinsAnimalsDiabetes, gestationalFatty-acidsFemaleFetal developmentFetal growth retardationGestational diabetes mellitusGestational diabetes-mellitusHormone-sensitive lipaseHumansHyperlipidemiaInsulin-resistanceIntrauterine growth restrictionLipid metabolismLipoprotein-lipase activityMaternal serum triglycerideNon-esterified fatty acidsNonesterified fatty acidsPlacentaPregnancyPregnancy complicationsRat adipose-tissueUmbilical-cord serum

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal CURRENT PHARMACEUTICAL BIOTECHNOLOGY due to its progression and the good impact it has achieved in recent years, according to the agency Scopus (SJR), it has become a reference in its field. In the year of publication of the work, 2014, it was in position , thus managing to position itself as a Q1 (Primer Cuartil), in the category Pharmaceutical Science.

From a relative perspective, and based on the normalized impact indicator calculated from World Citations provided by WoS (ESI, Clarivate), it yields a value for the citation normalization relative to the expected citation rate of: 4.51. This indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: ESI Nov 13, 2025)

This information is reinforced by other indicators of the same type, which, although dynamic over time and dependent on the set of average global citations at the time of their calculation, consistently position the work at some point among the top 50% most cited in its field:

  • Weighted Average of Normalized Impact by the Scopus agency: 6.07 (source consulted: FECYT Mar 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2026-04-04, the following number of citations:

  • WoS: 192
  • Scopus: 215
  • Europe PMC: 152
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Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2026-04-04:

  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 244 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

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    Leadership analysis of institutional authors

    There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (HERRERA CASTILLON, EMILIO) and Last Author (ORTEGA SENOVILLA, HENAR).

    the author responsible for correspondence tasks has been HERRERA CASTILLON, EMILIO.

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