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Analysis of institutional authors

Iturrieta-Zuazo IAuthor

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September 2, 2020
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Possible role of HLA class-I genotype in SARS-CoV-2 infection and progression: A pilot study in a cohort of Covid-19 Spanish patients

Publicated to: CLINICAL IMMUNOLOGY. 219 (108572): 108572-108572 - 2020-10-01 219(108572), DOI: 10.1016/j.clim.2020.108572

Authors:

Iturrieta-Zuazo I, Rita CG, García-Soidán A, de Malet Pintos-Fonseca A, Alonso-Alarcón N, Pariente-Rodríguez R, Tejeda-Velarde A, Serrano-Villar S, Castañer-Alabau JL, Nieto-Gañán I
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Affiliations

‎ Hosp Univ Marques de Valdecilla, Microbiol Dept, Santander, Spain - Author
‎ Hosp Univ Ramon y Cajal, Immunol Dept, Madrid, Spain - Author
‎ Hosp Univ Ramon y Cajal, Infect Dis Dept, Madrid, Spain - Author
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Abstract

Human Leukocyte Antigen (HLA) includes a large set of genes with important actions in immune response against viral infection. Numerous studies have revealed the existence of significant associations between certain HLA alleles and the susceptibility and prognosis of different infectious diseases. In this pilot study we analyse the binding affinity between 66 class I HLA alleles and SARS-CoV-2 viral peptides, and its association with the severity of the disease. A total of 45 Spanish patients with mild, moderate and severe SARS-CoV-2 infection were typed for HLA class I; after that, we analysed if an in silico model of HLA I-viral peptide binding affinity and classical HLA supertypes could be correlated to the severity of the disease. Our results suggest that patients with mild disease present Class I HLA molecules with a higher theoretical capacity for binding SARS-Cov-2 peptides and showed greater heterozygosity when comparing them with moderate and severe groups. In this regard, identifying HLA-SARS-CoV-2 peptides binding differences between individuals would help to clarify the heterogeneity of clinical responses to the disease and will also be useful to guide a personalized treatment according to its particular risk.Copyright © 2020 Elsevier Inc. All rights reserved.
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Keywords

AdultAgedAllelesAssociationBetacoronavirusCoronavirus infectionsCovid-19Disease progressionEvolution diseaseFemaleGene expressionGene frequencyHistocompatibility antigens class iHla class iHost-pathogen interactionsHumansImmunity, innateMaleMiddle agedMoleculesPandemicsPeptidesPilot projectsPneumonia, viralProtein bindingResistanceSars-cov-2Severity of illness indexSpainViral peptide-mhc class i binding affinityViral proteins

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal CLINICAL IMMUNOLOGY due to its progression and the good impact it has achieved in recent years, according to the agency Scopus (SJR), it has become a reference in its field. In the year of publication of the work, 2020, it was in position , thus managing to position itself as a Q2 (Segundo Cuartil), in the category Immunology and Allergy. Notably, the journal is positioned en el Cuartil Q3 for the agency WoS (JCR) in the category Immunology.

From a relative perspective, and based on the normalized impact indicator calculated from World Citations provided by WoS (ESI, Clarivate), it yields a value for the citation normalization relative to the expected citation rate of: 2. This indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: ESI Nov 13, 2025)

This information is reinforced by other indicators of the same type, which, although dynamic over time and dependent on the set of average global citations at the time of their calculation, consistently position the work at some point among the top 50% most cited in its field:

  • Weighted Average of Normalized Impact by the Scopus agency: 2.41 (source consulted: FECYT Mar 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2026-04-05, the following number of citations:

  • WoS: 58
  • Scopus: 76
  • Europe PMC: 64
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Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2026-04-05:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 145.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 145 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 21.
  • The number of mentions on the social network X (formerly Twitter): 14 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.
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Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: Israel.

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (ITURRIETA ZUAZO, IGNACIO) .

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