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Analysis of institutional authors

Saiz JAuthorGil-De-La-Fuente AAuthorBarbas CAuthorGradillas ACorresponding Author

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April 13, 2023
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Integrating the potential of ion mobility spectrometry-mass spectrometry in the separation and structural characterisation of lipid isomers

Publicated to: Frontiers in Molecular Biosciences. 10 1112521-1112521 - 2023-03-16 10(), DOI: 10.3389/fmolb.2023.1112521

Authors:

Camunas-Alberca, SM; Moran-Garrido, M; Sáiz, J; Gil-de-la-Fuente, A; Barbas, C; Gradillas, A
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Affiliations

CEU Univ, Univ San Pablo CEU, Escuela Politecn Super, Dept Tecnol Informac, Boadilla Del Monte, Spain - Author
CEU Univ, Univ San Pablo CEU, Fac Farm, Ctr Metabol & Bioanal CEMBIO, Boadilla Del Monte, Spain - Author
Universidad San Pablo-CEU - Author
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Abstract

It is increasingly evident that a more detailed molecular structure analysis of isomeric lipids is critical to better understand their roles in biological processes. The occurrence of isomeric interference complicates conventional tandem mass spectrometry (MS/MS)-based determination, necessitating the development of more specialised methodologies to separate lipid isomers. The present review examines and discusses recent lipidomic studies based on ion mobility spectrometry combined with mass spectrometry (IMS-MS). Selected examples of the separation and elucidation of structural and stereoisomers of lipids are described based on their ion mobility behaviour. These include fatty acyls, glycerolipids, glycerophospholipids, sphingolipids, and sterol lipids. Recent approaches for specific applications to improve isomeric lipid structural information using direct infusion, coupling imaging, or liquid chromatographic separation workflows prior to IMS-MS are also discussed, including: 1) strategies to improve ion mobility shifts; 2) advanced tandem MS methods based on activation of lipid ions with electrons or photons, or gas-phase ion-molecule reactions; and 3) the use of chemical derivatisation techniques for lipid characterisation.
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Keywords

double-bond positionidentificationlipid isomerslipidomicsliquid-chromatographymass spectrometry (ms)ozone-induced dissociationplatformquantitationresolutionresolving powerselectivityseparationshotgun lipidomicsstereoisomersstructural isomersCollision cross-sectionIdentificationIon mobility spectrometry (ims)Lipid isomersLipidomicsMass spectrometry (ms)SeparationStereoisomersStructural isomers

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Frontiers in Molecular Biosciences due to its progression and the good impact it has achieved in recent years, according to the agency Scopus (SJR), it has become a reference in its field. In the year of publication of the work, 2023, it was in position , thus managing to position itself as a Q1 (Primer Cuartil), in the category Biochemistry, Genetics and Molecular Biology (Miscellaneous).

From a relative perspective, and based on the normalized impact indicator calculated from World Citations provided by WoS (ESI, Clarivate), it yields a value for the citation normalization relative to the expected citation rate of: 3.95. This indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: ESI Nov 13, 2025)

This information is reinforced by other indicators of the same type, which, although dynamic over time and dependent on the set of average global citations at the time of their calculation, consistently position the work at some point among the top 50% most cited in its field:

  • Weighted Average of Normalized Impact by the Scopus agency: 3.68 (source consulted: FECYT Mar 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2026-04-05, the following number of citations:

  • WoS: 26
  • Scopus: 28
  • Europe PMC: 3
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Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2026-04-05:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 45.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 45 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 2.
  • The number of mentions on the social network X (formerly Twitter): 4 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.
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Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (Camunas-Alberca SM) and Last Author (GRADILLAS NICOLAS, ANA).

the author responsible for correspondence tasks has been GRADILLAS NICOLAS, ANA.

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Awards linked to the item

Funding This research was funded by the Ministry of Science and Innovation of Spain (MICINN) and the European Regional Development Fund FEDER, Grant Number PID 2021-122490NB-I00.
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