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Analysis of institutional authors

Escribese, Maria M MAuthorIzquierdo-Alvarez, ElenaAuthorBarber, DomingoCorresponding Author

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September 13, 2023
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The Role of Sphingolipids in Allergic Disorders

Publicated to: Front Allergy. 2 675557- - 2021-06-14 2(), DOI: 10.3389/falgy.2021.675557

Authors: Diaz-Perales, Araceli; Escribese, Maria M M; Garrido-Arandia, Maria; Obeso, David; Izquierdo-Alvarez, Elena; Tome-Amat, Jaime; Barber, Domingo

Affiliations

Univ Politecn Madrid UPM, Ctr Biotecnol & Genomica Plantas CBGP, Inst Nacl Invest & Tecnol Agr & Alimentaria INIA, Madrid, Spain - Author
Univ San Pablo CEU, CEU Univ, Fac Farm, Ctr Excelencia Metabol & Bioanal CEMBIO, Madrid, Spain - Author
Univ San Pablo CEU, CEU Univ, Inst Med Mol Aplicada IMMA, Fac Med,Basic Med Sci Dept, Madrid, Spain - Author
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Abstract

Allergy is defined as a complex chronic inflammatory condition in which genetic and environmental factors are implicated. Sphingolipids are involved in multiple biological functions, from cell membrane components to critical signaling molecules. To date, sphingolipids have been studied in different human pathologies such as neurological disorders, cancer, autoimmunity, and infections. Sphingolipid metabolites, in particular, ceramide and sphingosine-1-phosphate (S1P), regulate a diverse range of cellular processes that are important in immunity and inflammation. Moreover, variations in the sphingolipid concentrations have been strongly associated with allergic diseases. This review will focus on the role of sphingolipids in the development of allergic sensitization and allergic inflammation through the activation of immune cells resident in tissues, as well as their role in barrier remodeling and anaphylaxis. The knowledge gained in this emerging field will help to develop new therapeutic options for allergic disorders.

Keywords

1-phosphate17q21AllergyAssociationBarrier functionCeramide-1-pChildhood asthmaDisruption epithelial barrierInflammationInnate lymphoid-cellsLangerhans cellsSphigosine-1-pSphingolipidSphingosine-1-phosphateStratum-corneum lipids

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Front Allergy, Q4 Agency Scopus (SJR), its regional focus and specialization in Immunology and Allergy, give it significant recognition in a specific niche of scientific knowledge at an international level.

From a relative perspective, and based on the normalized impact indicator calculated from World Citations from Scopus Elsevier, it yields a value for the Field-Weighted Citation Impact from the Scopus agency: 1.22, which indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: ESI Nov 13, 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-12-07, the following number of citations:

  • WoS: 15
  • Scopus: 24
  • Europe PMC: 9

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-12-07:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 24.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 24 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 1.
  • The number of mentions on the social network X (formerly Twitter): 2 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.

Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: Last Author (BARBER HERNANDEZ, DOMINGO).

the author responsible for correspondence tasks has been BARBER HERNANDEZ, DOMINGO.

Awards linked to the item

This research was funded by the Spanish Government (MINECO, grant BIO2017-84548-R); by Instituto de Salud Carlos III (ISCIII) (PI19/00044); by ISCIII co-founded by FEDER Thematic Networks and Cooperative Research Centres: ARADYAL (RD16/0006/0003; RD16/0006/0015); and by Community of Madrid (FOODAL-CM_S2018/BAAA-4574). JT-A was funded by Instituto de Salud Carlos III (ISCIII), co-founded by FEDER Thematic Networks and Cooperative Research Centres: ARADYAL (RD16/0006/0003).