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Instituto de Salud Carlos III COV20_00622 Angel Carracedo Instituto de Salud Carlos III COV20/00792 Matilde Bustos Instituto de Salud Carlos III COV20_00181 Carmen Ayuso Instituto de Salud Carlos III COV20_1144 Amanda Fernandez-Rodriguez Maria A Jimenez-Sousa Instituto de Salud Carlos III PI20/00876 Carlos Flores European Regional Development Fund A way of making Europe Angel Carracedo Fundacion Amancio Ortega Angel Carracedo Banco Santander Angel Carracedo Estrella de Levante S.A. Encarna Guillen-Navarro Colabora Mujer Association Encarna Guillen-Navarro Obra Social La Caixa Raul C Baptista-Rosas Agencia Estatal de Investigacion RTC-2017-6471-1 Carlos Flores Cabildo Insular de Tenerife CGIEU0000219140 Carlos Flores Fundacion Canaria Instituto de Investigacion Sanitaria de Canarias PIFIISC20/57 Carlos Flores Xunta de Galicia Silvia Diz-de Almeida Axencia GAIN Silvia Diz-de Almeida The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.

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Novel risk loci for COVID-19 hospitalization among admixed American populations

Publicado en:Elife. 13 RP93666- - 2024-10-03 13(), DOI: 10.7554/eLife.93666

Autores: Diz-de Almeida, Silvia; Cruz, Raquel; Luchessi, Andre D; Lorenzo-Salazar, Jose M; Lopez de Heredia, Miguel; Quintela, Ines; Gonzalez-Montelongo, Rafaela; Nogueira Silbiger, Vivian; Sevilla Porras, Marta; Tenorio Castano, Jair Antonio; Nevado, Julian; Maria Aguado, Jose; Aguilar, Carlos; Aguilera-Albesa, Sergio; Almadana, Virginia; Almoguera, Berta; Alvarez, Nuria; Andreu-Bernabeu, lvaro; Arana-Arri, Eunate; Arango, Celso; Arranz, Maria J; Artiga, Maria-Jesus; Baptista-Rosas, Raul C; Barreda- Sanchez, Maria; Belhassen-Garcia, Moncef; Bezerra, Joao F; Bezerra, Marcos A C; Boix-Palop, Lucia; Brion, Maria; Brugada, Ramon; Bustos, Matilde; Calderon, Enrique J; Carbonell, Cristina; Castano, Luis; Castelao, Jose E; Conde-Vicente, Rosa; Cordero-Lorenzana, M Lourdes; Cortes-Sanchez, Jose L; Corton, Marta; Teresa Darnaude, M; De Martino-Rodriguez, Alba; del Campo-Perez, Victor; de Bustamante, Aranzazu Diaz; Dominguez-Garrido, Elena; Eiros, Rocio; Carmen Farinas, Maria; Fernandez-Nestosa, Maria J; Fernandez-Robelo, Uxia; Fernandez-Rodriguez, Amanda; Fernandez-Villa, Tania; Gago-Dominguez, Manuela; Gil-Fournier, Belen; Gomez-Arrue, Javier; Alvarez, Beatriz Gonzalez; Bernaldo de Quiros, Fernan Gonzalez; Gonzalez-Neira, Anna; Gonzalez-Penas, Javier; Gutierrez-Bautista, Juan F; Herrero, Maria Jose; Herrero-Gonzalez, Antonio; Jimenez-Sousa, Maria A; Claudia Lattig, Maria; Liger Borja, Anabel; Lopez-Rodriguez, Rosario; Mancebo, Esther; Martin-Lopez, Caridad; Martin, Vicente; Martinez-Nieto, Oscar; Martinez-Lopez, Iciar; Martinez-Resendez, Michel F; Martinez-Perez, Angel; Mazzeu, Juliana F; Merayo Macias, Eleuterio; Minguez, Pablo; Cuerda, Victor Moreno; Oliveira, Silviene F; Ortega-Paino, Eva; Parellada, Mara; Paz-Artal, Estela; Santos, Ney P C; Perez-Matute, Patricia; Perez, Patricia; Perez-Tomas, M Elena; Perucho, Teresa; Pinsach-Abuin, Mellina; Pita, Guillermo; Pompa-Mera, Ericka N; Porras-Hurtado, Gloria L; Pujol, Aurora; Ramiro Leon, Soraya; Resino, Salvador; Fernandes, Marianne R; Rodriguez-Ruiz, Emilio; Rodriguez-Artalejo, Fernando; Rodriguez-Garcia, Jose A; Ruiz-Cabello, Francisco; Ruiz-Hornillos, Javier; Ryan, Pablo; Manuel Soria, Jose; Carlos Souto, Juan; Tamayo, Eduardo; Tamayo-Velasco, Alvaro; Taracido-Fernandez, Juan Carlos; Teper, Alejandro; Torres-Tobar, Lilian; Urioste, Miguel; Valencia-Ramos, Juan; Yanez, Zuleima; Zarate, Ruth; de Rojas, Itziar; Ruiz, Agustin; Sanchez, Pascual; Real, Luis Miguel; Guillen-Navarro, Encarna; Ayuso, Carmen; Parra, Esteban; Riancho, Jose A; Rojas-Martinez, Augusto; Flores, Carlos; Lapunzina, Pablo; Carracedo, Angel

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Resumen

The genetic basis of severe COVID-19 has been thoroughly studied, and many genetic risk factors shared between populations have been identified. However, reduced sample sizes from non-European groups have limited the discovery of population-specific common risk loci. In this second study nested in the SCOURGE consortium, we conducted a genome-wide association study (GWAS) for COVID-19 hospitalization in admixed Americans, comprising a total of 4702 hospitalized cases recruited by SCOURGE and seven other participating studies in the COVID-19 Host Genetic Initiative. We identified four genome-wide significant associations, two of which constitute novel loci and were first discovered in Latin American populations (BAZ2B and DDIAS). A trans-ethnic meta-analysis revealed another novel cross-population risk locus in CREBBP. Finally, we assessed the performance of a cross-ancestry polygenic risk score in the SCOURGE admixed American cohort. This study constitutes the largest GWAS for COVID-19 hospitalization in admixed Latin Americans conducted to date. This allowed to reveal novel risk loci and emphasize the need of considering the diversity of populations in genomic research.

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