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Analysis of institutional authors

Barbas, CoralAuthorBarber, DomingoAuthorVillasenor, AlmaCorresponding Author

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September 19, 2025
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Multi-omics analysis of a prebiotic intervention with pectin in lipid transfer proteins (LTPs) allergic patients

Publicated to: CARBOHYDRATE POLYMERS. 369 124236- - 2025-12-01 369(), DOI: 10.1016/j.carbpol.2025.124236

Authors:

Gómez, F; Pérez-Sánchez, N; Macías-Camero, A; Núñez, R; Contreras, N; Cañas, JA; Jiménez-Sánchez, IM; Díez-Echave, P; Barbas, C; Guéant, JL; Barber, D; Vieths, S; Scheurer, S; Villaseñor, A; Rodríguez-Nogales, A; Mayorga, C; Torres, MJ
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Affiliations

Fed Inst Vaccines & Biomed, Paul Ehrlich Inst, Mol Allergol, Langen, Germany - Author
Hosp Reg Univ Malaga, Allergy Clin Unit, Malaga, Spain - Author
Inst Invest Biomed Malaga & Plataforma Nanomed IBI, Allergy Res Grp, Malaga, Spain - Author
Inst Invest Biosanit Ibs GRANDA, Granada, Spain - Author
Univ Granada, Ctr Biomed Res CIBM, Pharmacol Dept, Granada, Spain - Author
Univ Hosp Nancy, Dept Mol Med, Div Biochem Mol Biol & Nutr, Vandoeuvre Les Nancy, France - Author
Univ Hosp Nancy, Reference Ctr Inborn Errors Metab ORPHA67872, Vandoeuvre Les Nancy, France - Author
Univ Lorraine, Fac Med Nancy, Nutr Genet & Environm Risk Exposure, INSERM,UMR S1256, Vandoeuvre Les Nancy, France - Author
Univ Malaga UMA, Med Dept, Malaga, Spain - Author
Univ San Pablo CEU, CEU Univ, Dept Ciencias Med Bas, Inst Med Mol Aplicada Nemesio Diez IMMA ND,Fac Med, Boadilla Del Monte, Spain - Author
Univ San Pablo, CEU Univ, Fac Farm, Ctr Metabol & Bioanal, Boadilla Del Monte, Spain - Author
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Abstract

Currently, there is great interest in the use of pectins for prebiotic treatment of food allergy. Hence, the effects of two different esterified pectins - low methoxyl citrus-derived pectin (CP-DElow) and high methoxyl apple-derived pectin (AP-DEhigh) - were evaluated in peach allergic patients due to sensitization to lipid transfer proteins (LTPs). This study analyzed the systemic immune response, the gut microbiota composition (using 16S rRNA gene sequencing), and microbial-derived metabolome, including short-chain fatty acids (SCFAs) and bile acids (BAs). Prebiotic treatment with both pectins was safe and induced a significant clinical increase in allergen tolerance in more than 50 % of patients. Additionally, CP-DElow and AP-DEhigh groups exhibited a distinctive systemic proteomic profile characterized by a decrease in various inflammatory cytokines compared to Placebo. Regarding microbiota, CP-DElow induced an increase in Bacteroides_H genus and Roseburia intestinalis species, whereas AP-DEhigh was associated with an increase in Bifidobacterium and Succinivibrio genera, and Faecalibacterium prausnitzii species. Reduced concentrations of branched SCFAs were observed after both treatments compared to Placebo. Likewise, fecal levels of microbial-derived secondary BAs were modified by pectin supplementation. Multi-omics integration revealed distinctive signatures in pectin- and placebo-treated patients. This study suggests that pectin treatment is a promising and safe option for LTP allergy.
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Keywords

AdultCarrier proteinsFatty acids, volatileFemaleFibersFood allergyFood hypersensitivityGastrointestinal microbiomeHumansLipid transfer proteinMaleMalusMechanismsMetabolomicsMetagenomisMicrobiomeMultiomicsNutritionPeachPectinPectinsPrebioticsProteomicsYoung adult

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal CARBOHYDRATE POLYMERS due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2025, it was in position 1/57, thus managing to position itself as a Q1 (Primer Cuartil), in the category Chemistry, Organic. Notably, the journal is positioned above the 90th percentile.

Independientemente del impacto esperado determinado por el canal de difusión, es importante destacar el impacto real observado de la propia aportación.

Según las diferentes agencias de indexación, el número de citas acumuladas por esta publicación hasta la fecha 2026-04-24:

  • WoS: 1
  • Scopus: 1
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Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2026-04-24:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 9.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 7 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 1.
  • The number of mentions on the social network X (formerly Twitter): 1 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.
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Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: France; Germany; Granada.

the author responsible for correspondence tasks has been VILLASEÑOR SOLIS, ALMA CRISTINA.

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Awards linked to the item

This study was supported by the following grants: Carlos III Health Institute, the Ministry of Science and Innovation in Spain, and the European program ERA HDHL (PI17/01318, PI18/00288 and AC18/00031) ; "Una manera de hacer Europa" and "Andalucia se mueve con Europa" programs from the European Regional Development Fund (ERDF) (PI21/00346 and PI21/01391) ; "Red Tematica de Investigacion Cooperativa en Salud" (RETICS) ARADyAL (RD16/0006/0001 and RD16/0006/0015) ; IBIMA Predoctoral Health Research Training Funding (FI22/00106 and FI22/00199) , Sara Borrell (CD20/00085) and Juan Rodes (JR21/00024) grants; RICORS "Red de Enfermedades Inflamatorias (REI) " (RD21/0002/0008 and RD24/0007/0018) ; the Andalusian Regional Ministry of Health (PE-0039-2018 and PI-0047-2022) . The present study is also part of an IGF Project of the FEI which is supported via AiF (AiF20528) within the program for promoting the Industrial Collective Research (IGF) of the German Ministry of Economic Affairs and Research (BMWi) . A.M-C. and N.C. are supported by an FPI-CEU predoctoral fellowship from San Pablo-CEU University Foundation. Additionally, A.M-C. also acknowledges her EAACI 2024 Research Fellowship from the European Academy of Allergy and Clinical Immunology (EAACI) for her international research mobility in the Karolinska Institutet (Stockholm, Sweden) . A.V. acknowledges financial support from "Programa Ayudas Puente 2024-2025" from San Pablo CEU University Foundation, and grant number PEJ-2023-AI/SAL-GL-27622 from the Community of Madrid. D.B. (PI19/00044 and PI24/00992) and A.R-N. (PI20/01447) acknowledge financial support from Carlos III Health Institute. C.M. acknowledges a "Nicolas Monardes" research contract (RC0004-2021) and a grant from the Andalusian Regional Ministry of Economy and Knowledge in partnership with the University of Malaga (UMA20-FEDERJA-151) . Authors would also like to thank all institutions and hospitals involved: Hospital Regional Universitario de Malaga (Malaga, Spain) , Institute of Applied Molecular Medicine (IMMA-ND, San Pablo-CEU University, Madrid, Spain) , Centre for Metabolomics and Bioanalysis (CEMBIO, San Pablo-CEU University, Madrid, Spain) , Paul-Ehrlich-Institut (PEI, Langen, Germany) , University of Lorraine (Vandoeuvre-les-Nancy, France) , Instituto de Investigacion Biosanitaria de Granada (ibs.GRANADA, Granada, Spain) , University of Granada (UGR, Granada Spain) , Instituto de Investigacion Biomedica de Malaga y Plataforma en Nanomedicina (IBIMA Plataforma BIONAND, Malaga, Spain) , and Uni-versidad de Malaga (UMA, Ma laga, Spain) . Authors would personally like to thank Prof. Santiago Angulo for his statistics advise and Matlab script development; Paloma Fernandez, Luis Senador Zaldivar and Ricardo Arroyo for the technical support in the proteomic analysis at IMMA-ND; and Prof. Dr. Hans-Ulrich Endre ss (Herbstreith & Fox, Neu-enbuerg, Germany) for providing the pectin.
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