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Analysis of institutional authors

Zapico J.m.AuthorRamos A.AuthorDe Pascual-Teresa B.Author

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January 29, 2014
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MMP-2 selectivity in hydroxamate-type inhibitors

Publicated to: Current Medicinal Chemistry. 19 (7): 1036-1064 - 2012-03-01 19(7), DOI: 10.2174/092986712799320628

Authors:

Serra, P; Bruczko, M; Zapico, JM; Puckowska, A; García, MA; Martín-Santamaría, S; Ramos, A; de Pascual-Teresa, B
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Affiliations

Department of Chemistry, Universidad CEU San Pablo, Madrid, Spain. - Author
Med Univ Bialystok, Fac Pharm, Dept Med Chem, Bialystok, Poland - Author
Med Univ Bialystok, Fac Pharm, Dept Organ Chem, Bialystok, Poland - Author
Univ CEU San Pablo, Fac Farm, Dept Chem, Madrid 28668, Spain - Author
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Abstract

Extracellular matrix metalloproteinases (MMPs) are a family of zinc-dependent neutral endopeptidases involved in physiological and pathological processes, through the cleavage of extracellular matrix. MMPs are capable of degrading essentially all matrix components, which is crucial for malignant tumor growth, invasion, metastasis and angiogenesis. The vertebrates MMP family includes at least 26 enzymes (23 have been known in humans) with only MMP-1, 2, and 7 experimentally validated as targets for antitumoral drug design. However, inhibition of MMP-1 has been hypothesized to be the cause of the clinically observed musculoskeletal syndrome when broad spectrum inhibitors are used. On the other hand, MMP-9 is a tricky enzyme, since its inhibition might be useful in treating patients with early-stage cancers, but MMP-9 is an anti-target in patients with advanced disease. So, MMP-9 inhibition should also be prevented. Therefore, selective MMP-2 inhibition arises as a pursued profile for MMP binders. Among them, hydroxamates have been extensively studied as small molecule drug candidates characterized by an effective zinc-binding group plus additional side chains responsible for the selectivity. This article pays particular attention to MMP-2 selectivity on hydroxamate-type inhibitors, especially against MMP-9, and their chemical structure, SAR, general synthetic methods, and molecular modelling studies are here reviewed in order to inspire further design of new effective anticancer agents.
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Keywords

Antineoplastic agentsDrug designEnzyme activationHumansHydroxamateHydroxamic acidsMatrix metalloproteinase 2Matrix metalloproteinase inhibitorsModels, molecularMolecular modellingPatient selectionSelective matrix metalloproteinase-2 inhibitorsStructure-activity relationshipSynthesis

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Current Medicinal Chemistry due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2012, it was in position 80/290, thus managing to position itself as a Q1 (Primer Cuartil), in the category Biochemistry & Molecular Biology.

Independientemente del impacto esperado determinado por el canal de difusión, es importante destacar el impacto real observado de la propia aportación.

Según las diferentes agencias de indexación, el número de citas acumuladas por esta publicación hasta la fecha 2026-01-20:

  • WoS: 29
  • Scopus: 29
  • Europe PMC: 16
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Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2026-01-20:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 16.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 16 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 3.
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Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: Netherlands; Poland.

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (Serra P.) and Last Author (PASCUAL-TERESA FERNANDEZ, BEATRIZ).

the author responsible for correspondence tasks has been Martín-Santamarí S..

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