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The authors have no conflicts of interest to declare. This research work was supported by the Ministerio de Sanidad, Servicios Sociales e Igualdad (Plan Nacional sobre Drogas, PNSD2016I025), Spain.

Analysis of institutional authors

Polanco Mora, María JoséCorresponding AuthorDolores Perez-Carrion, MariaAuthorAlguacil L.f.AuthorGonzález-Martín CAuthor

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May 19, 2021
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Clusterin levels in undernourished SH-SY5Y cells

Publicated to:Food & Nutrition Research. 65 (5709): 5709- - 2021-05-04 65(5709), DOI: 10.29219/fnr.v65.5709

Authors: Rodriguez-Rivera, Carmen; Dolores Perez-Carrion, Maria; Casariego Olavarria, Lucia; Alguacil, Luis F; Polanco Mora, Maria Jose; Gonzalez-Martin, Carmen

Affiliations

Facultad de Farmacia, Instituto de Estudio de las Adicciones, Universidad CEU San Pablo, Alcorcón, Madrid, Spain. - Author
Facultad de Farmacia, Universidad CEU San Pablo, Alcorcón, Madrid, Spain. - Author
Facultad de Medicina, Universidad de Castilla-la Mancha, Albacete, Spain. - Author
‎ Univ Castilla La Mancha, Fac Med, Albacete, Spain - Author
‎ Univ CEU San Pablo, Fac Farm, Campus Monteprincipe, ES-28925 Madrid, Spain - Author
‎ Univ CEU San Pablo, Fac Farm, Inst Estudio Adicc, Madrid, Spain - Author
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Abstract

Food-related disorders are increasingly common in developed societies, and the psychological component of these disorders has been gaining increasing attention. Both overnourishment with high-fat diets and perinatal undernourishment in mice have been linked to a higher motivation toward food, resulting in an alteration in food intake. Clusterin (CLU), a multifaced protein, is overexpressed in the nucleus accumbens (NAc) of over-fed rats, as well as in those that suffered chronic undernutrition. Moreover, an increase of this protein was observed in the plasma of obese patients with food addiction, suggesting the implication of CLU in this eating disorder. To characterize CLU's cellular mechanisms, in vitro experiments of undernutrition were performed using dopaminergic SH-SY5Y cells. To mimic in vivo dietary conditions, cells were treated with different fetal bovine serum (FBS) concentrations, resulting in control (C group) diet (10% FBS), undernourishment (U group) diet (0.5% FBS), and undernourishment diet followed by restoration of control diet (UC group) (0.5 + 10% FBS). Undernourishment compromised cell viability and proliferation, and concomitantly increased CLU secretion as well as the cytosolic pool of the protein, while decreasing the mitochondrial level. The restoration of normal conditions tended to recover cell physiology, and the normal levels and distribution of CLU. This research study is a step forward toward the characterization of clusterin as a potential marker for food addiction and nutritional status.© 2021 Carmen Rodríguez Rivera et al.

Keywords

cell survivalclusterinfood addictionmitochondriaApoptosisCell survivalClusterinDopamineFood addictionGlycosylationMitochondriaObesityRetrotranslocationRewardSeekingStressStriatumUndernutrition

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Food & Nutrition Research due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2021, it was in position 72/144, thus managing to position itself as a Q2 (Segundo Cuartil), in the category Food Science & Technology. Notably, the journal is positioned en el Cuartil Q2 para la agencia Scopus (SJR) en la categoría Food Science.

Independientemente del impacto esperado determinado por el canal de difusión, es importante destacar el impacto real observado de la propia aportación.

Según las diferentes agencias de indexación, el número de citas acumuladas por esta publicación hasta la fecha 2025-07-06:

  • Europe PMC: 1

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-07-06:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 29.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 29 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 6.75.
  • The number of mentions on the social network X (formerly Twitter): 9 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.

Leadership analysis of institutional authors

There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (Rodriguez-Rivera, Carmen) and Last Author (GONZALEZ MARTIN, CARMEN).

the authors responsible for correspondence tasks have been POLANCO MORA, MARIA JOSE and Rodriguez-Rivera, Carmen.