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LDRB is a doctoral student from Programa de Doctorado en Ciencias Biomedicas, Universidad Nacional Autonoma de Mexico and received fellowship #229328 from Consejo Nacional de Ciencia y Tecnologia (http://www.conacyt.gob.mx). Laboratory funding was provided by Consejo Nacional de Ciencia y Tecnologia grant #177962, Programa de Apoyo a Proyectos de Investigacion e Innovacion Tecnologica de la Universidad Nacional Autonoma de Mexico (http://dgapa.unam.mx/html/papiit/papit.html), grant #IN203110, and laboratory budget to JRRE. MD is a grant recipient form the Spanish National Grants (BFU2009-09074, SAF2012-35181 and MEC-CONSOLIDER CSD2007-00023), Generalitat Valenciana Grant (PROMETEO II/2013/001) and Fundacion Botin. IGP is a grant recipient from the IFP, Spain. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Analysis of institutional authors

Gutierrez-Perez, IreneAuthor

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June 2, 2021
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acal is a Long Non-coding RNA in JNK Signaling in Epithelial Shape Changes during Drosophila Dorsal Closure

Publicated to:Plos Genetics. 11 (2): e1004927- - 2015-02-01 11(2), DOI: 10.1371/journal.pgen.1004927

Authors: Daniel Rios-Barrera, Luis; Gutierrez-Perez, Irene; Dominguez, Maria; Riesgo-Escovar, Rafael

Affiliations

Univ Miguel Hernandez, CSIC, Inst Neurociencias, Alicante, Spain - Author
Univ Nacl Autonoma Mexico, Inst Neurobiol, Queretaro, Mexico - Author

Abstract

Dorsal closure is an epithelial remodeling process taking place during Drosophila embryogenesis. JNK signaling coordinates dorsal closure. We identify and characterize acal as a novel negative dorsal closure regulator. acal represents a new level of JNK regulation. The acal locus codes for a conserved, long, non-coding, nuclear RNA. Long non-coding RNAs are an abundant and diverse class of gene regulators. Mutations in acal are lethal. acal mRNA expression is dynamic and is processed into a collection of 50 to 120 bp fragments. We show that acal lies downstream of raw, a pioneer protein, helping explain part of raw functions, and interacts genetically with Polycomb. acal functions in trans regulating mRNA expression of two genes involved in JNK signaling and dorsal closure: Connector of kinase to AP1 (Cka) and anterior open (aop). Cka is a conserved scaffold protein that brings together JNK and Jun, and aop is a transcription factor. Misregulation of Cka and aop can account for dorsal closure phenotypes in acal mutants.

Keywords

Acal long non-coding rna, drosophilaAdaptor proteins, signal transducingAnimalsAop protein, drosophilaBody patterningCell morphogenesisCka protein, drosophilaDistinct rolesDrosophila melanogasterDrosophila proteinsEncodesEpithelial cellsEye proteinsFinger proteinGene expression regulation, developmentalGenomeIdentificationMap kinase signaling systemMelanogasterMessenger-rnaMutationN-terminal kinasePathwayPhenotypePolycomb-group proteinsRepressor proteinsRna, long noncodingSignal transduction

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Plos Genetics due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2015, it was in position 15/166, thus managing to position itself as a Q1 (Primer Cuartil), in the category Genetics & Heredity.

From a relative perspective, and based on the normalized impact indicator calculated from the Field Citation Ratio (FCR) of the Dimensions source, it yields a value of: 3.04, which indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: Dimensions Aug 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-08-21, the following number of citations:

  • WoS: 31
  • Europe PMC: 20

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-08-21:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 40.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 40 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 4.
  • The number of mentions on the social network Facebook: 1 (Altmetric).
  • The number of mentions on the social network X (formerly Twitter): 8 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.

Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: Mexico.