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Unzue, LAuthor

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September 5, 2022
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Paravalvular leaks: mechanisms, diagnosis and management

Publicated to: EuroIntervention. 8 Q41-Q52 - 2012-09-01 8(), DOI: 10.4244/EIJV8SQA9

Authors:

Garcia, Eulogio; Sandoval, Jorge; Unzue, Leire; Hernandez-Antolin, Rosana; Almeria, Carlos; Macaya, Carlos
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Affiliations

San Carlos Univ Hosp, Dept Cardiac, Cardiovasc Inst, Madrid, Spain - Author

Abstract

Aims: To understand the incidence, aetiology and mechanisms of paravalvular aortic and mitral leaks after valvular surgery; reviewing the best methods for diagnosis, procedural guidance and result assessment of these leaks, as well as describing the different approaches to their treatment.Methods and results: A literature search was undertaken as well as an in-depth analysis of our own experience concerning different imaging modalities and various therapeutic strategies for aortic and mitral paravalvular leaks. The majority of patients were diagnosed using two- or three-dimensional transoesophageal echocardiography, useful in both guiding the procedure as well as assessing the procedural results. Haemoglobin, haematocrit, LDH and haptoglobin values were analysed to assess haemolysis. Procedural success for percutaneous closure of paravalvular aortic leaks are around 90% in the different series, with low complication rates. Mitral leaks have been approached by transfemoral and transapical access; the reported success of this procedure ranges from 75% to more than 90% in different reports. Complication rates at 30 days average 10% and mortality related to the procedure is around 1%. Late follow-up results depend on the initial anatomy, baseline clinical class and procedure results.Conclusions: Paravalvular leaks after surgical valve implantation have a multifactorial aetiology, but are mainly related to specific anatomic characteristics of the valvular ring. Mitral leaks are three times more common than aortic leaks and the incidence increases after reoperation. Different percutaneous techniques with several devices have been explored for leak closure, but we are still lacking devices specifically designed to treat this pathology more effectively.
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Keywords

3-dimensional transesophageal echocardiographyAmplatzer vascular plugAortic-valve-replacementFollow-upImpingementMitral regurgitationParavalvular leakPercutaneous closurePercutaneous interventionPeriprosthetic leaksProsthetic regurgitationReoperationRepairTranscatheter closure

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal EuroIntervention due to its progression and the good impact it has achieved in recent years, according to the agency Scopus (SJR), it has become a reference in its field. In the year of publication of the work, 2012, it was in position , thus managing to position itself as a Q1 (Primer Cuartil), in the category Medicine (Miscellaneous). Notably, the journal is positioned above the 90th percentile.

Independientemente del impacto esperado determinado por el canal de difusión, es importante destacar el impacto real observado de la propia aportación.

Según las diferentes agencias de indexación, el número de citas acumuladas por esta publicación hasta la fecha 2026-04-05:

  • WoS: 24
  • Europe PMC: 13
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Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2026-04-05:

  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 42 (PlumX).
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