{rfName}
Ef

Indexed in

License and use

Icono OpenAccess

Citations

7

Altmetrics

Grant support

Authors wish to thank Brian Crilly for linguistic assistance.

Analysis of institutional authors

Acero, NuriaCorresponding AuthorMunoz-Mingarro, DoloresAuthorGradillas, AnaAuthor

Share

May 13, 2024
Publications
>
Article
Sí

Effects of Crocus sativus L. Floral Bio-Residues Related to Skin Protection

Publicated to:Antioxidants. 13 (3): 358- - 2024-03-01 13(3), DOI: 10.3390/antiox13030358

Authors: Acero, Nuria; Munoz-Mingarro, Dolores; Gradillas, Ana

Affiliations

Univ San Pablo CEU, CEU Univ, Fac Farm, Ctr Metabol & Bioanal CEMBIO,Urbanizac Monteprinci, Boadilla Del Monte 28660, Spain - Author
Univ San Pablo CEU, CEU Univ, Fac Farm, Dept Quim & Bioquim,Urbanizac Monteprincipe, Boadilla Del Monte 28660, Spain - Author
Univ San Pablo CEU, CEU Univ, Fac Farm, Urbanizac Monteprincipe,Dept CC Farmaceut & Salud, Boadilla Del Monte 28660, Spain - Author

Abstract

The cultivation of Crocus sativus L. to obtain the saffron spice generates a large amount of biowaste, constituted mainly by the flower's tepals. The aim of this work was to evaluate the antioxidant and dermo-protective effect of a complex methanolic extract of C. sativus tepals. The extract's major phenolic content was analyzed using ultra-high performance liquid chromatography with electrospray ionization, coupled with quadrupole-time-of-flight-mass spectrometry (UHPLC-ESI-QTOF-MS). Then, the antioxidant in vitro activity of the extract was studied and related to their chemical composition. Likewise, the effect on intracellular ROS levels in HepG2 and Hs27 cell culture was determined in normal culture and under hydrogen-peroxide-induced oxidative stress. Finally, tyrosinase, hyaluronidase, collagenase, elastase, and xanthine oxidase assays were carried out to determine the dermo-protective capacity of the extract. The high polyphenol content, including flavonoids and anthocyanins, explains the antioxidant effect of the extract both in vitro and in culture assays. The extract has a significant and remarkable protective capacity against oxidative stress induced in culture of the two studied cell lines. It is also remarkable in its ability to inhibit hyaluronidase, tyrosinase, and xanthine oxidase. Results pointed out this biowaste extract as a promising ingredient in the composition of cosmetics.

Keywords

AntiagingAntioxidantAntioxidant capacityCrocus sativus l.Dermo-protectionElastaseHyaluronidaseIn-vitroInhibitionOxidative stressPetals extractPhenolic compoundsPhenolic-compoundsSaffron bio-residuesSaffron flowerXanthine-oxidase

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Antioxidants due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2024 there are still no calculated indicators, but in 2023, it was in position 8/72, thus managing to position itself as a Q1 (Primer Cuartil), in the category Chemistry, Medicinal. Notably, the journal is positioned above the 90th percentile.

Independientemente del impacto esperado determinado por el canal de difusión, es importante destacar el impacto real observado de la propia aportación.

Según las diferentes agencias de indexación, el número de citas acumuladas por esta publicación hasta la fecha 2025-07-23:

  • WoS: 2
  • Scopus: 2
  • Europe PMC: 1

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-07-23:

  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 20 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

    It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

    • The work has been submitted to a journal whose editorial policy allows open Open Access publication.

    Leadership analysis of institutional authors

    There is a significant leadership presence as some of the institution’s authors appear as the first or last signer, detailed as follows: First Author (ACERO DE MESA, NURIA) and Last Author (GRADILLAS NICOLAS, ANA).

    the author responsible for correspondence tasks has been ACERO DE MESA, NURIA.